Chinese scientist He Jiankui, who previously sparked global controversy by creating the first gene-edited babies, is now focusing on using gene-editing to combat Alzheimer’s disease. His new research involves testing a genetic mutation that could potentially protect against dementia, starting with trials on mice. Despite his past ethical breaches, He is committed to adhering to…
Yale scientists have developed a new CRISPR tool, CRISPR-Cas12a, which allows for more seamless gene editing and the simultaneous assessment of multiple genetic changes. This advancement enables researchers to study complex genetic interactions and their effects on various diseases, including cancer. The new tool also facilitates the rapid generation of disease and treatment models, offering…
The article discusses Evo 2, the largest generative AI model for biology, developed by scientists at the Arc Institute, Stanford University, and Nvidia. Trained on 128,000 genomes, Evo 2 can write whole chromosomes and small genomes from scratch. It also analyzes DNA mutations affecting proteins, RNA, and overall health, particularly in non-coding regions linked to…
The article introduces NanoCas, a miniaturized version of the CRISPR-Cas9 gene editing tool developed by Mammoth Biosciences. NanoCas reduces the size of the Cas9 component to about one-third of its original size, enabling it to be delivered more effectively to various tissues in the body. This advancement addresses the delivery challenges of traditional CRISPR systems,…